See recent publications we have contributed to.

Selected Publications

• Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes. Hvidtfeldt M, Sverrild A, Pulga A, Frøssing L, Silberbrandt A, Hostrup M, Thomassen M, Sanden C, Clausson CM, Siddhuraj P, Bornesund D, Nieto-Fontarigo JJ, Uller L, Erjefält J, Porsbjerg C.J Allergy Clin Immunol. 2023 Mar 10:S0091-6749(23)00291-9. doi: 10.1016/j.jaci.2023.03.001. Online ahead of print.PMID: 36907566 Free article.
• Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19. Erjefält JS, de Souza Xavier Costa N, Jönsson J, Cozzolino O, Dantas KC, Clausson CM, Siddhuraj P, Lindö C, Alyamani M, Lombardi SCFS, Mendroni Júnior A, Antonangelo L, Faria CS, Duarte-Neto AN, de Almeida Monteiro RA, Rebello Pinho JR, Gomes-Gouvêa MS, Verciano Pereira R, Monteiro JS, Setubal JC, de Oliveira EP, Theodoro Filho J, Sanden C, Orengo JM, Sleeman MA, da Silva LFF, Saldiva PHN, Dolhnikoff M, Mauad T.EBioMedicine. 2022 Sep;83:104229. doi: 10.1016/j.ebiom.2022.104229. Epub 2022 Aug 24.PMID: 36027872 Free PMC article.
• Expansion of Phenotypically Altered Dendritic Cell Populations in the Small Airways and Alveolar Parenchyma in Patients with Chronic Obstructive Pulmonary Disease. Mori M, Clausson CM, Sanden C, Jönsson J, Andersson CK, Siddhuraj P, Shikhagaie M, Åkesson K, Bergqvist A, Löfdahl CG, Erjefält JS.J Innate Immun. 2022 Aug 23:1-16. doi: 10.1159/000526080. Online ahead of print.PMID: 35998572 Free article.
• Mucosal cryobiopsies: a new method for studying airway pathology in asthma. Hvidtfeldt M, Sverrild A, Pulga A, Frøssing L, Silberbrandt A, Sanden C, Clausson CM, Bornesund D, Erjefält J, Porsbjerg C.ERJ Open Res. 2022 Mar 21;8(1):00666-2021. doi: 10.1183/23120541.00666-2021. eCollection 2022 Jan.PMID: 35350284 Free PMC article.
• RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma. Lamb D, De Sousa D, Quast K, Fundel-Clemens K, Erjefält JS, Sandén C, Hoffmann HJ, Kästle M, Schmid R, Menden K, Delic D.Respir Res. 2021 May 22;22(1):158. doi: 10.1186/s12931-021-01743-7.PMID: 34022896 Free PMC article.
• Lung Mast Cells Have a High Constitutive Expression of Carboxypeptidase A3 mRNA That Is Independent from Granule-Stored CPA3. Siddhuraj P, Clausson CM, Sanden C, Alyamani M, Kadivar M, Marsal J, Wallengren J, Bjermer L, Erjefält JS.Cells. 2021 Feb 3;10(2):309. doi: 10.3390/cells10020309.PMID: 33546258 Free PMC article.
• Eosinophils, basophils and type 2 immune microenvironments in COPD-affected lung tissue. Jogdand P, Siddhuraj P, Mori M, Sanden C, Jönsson J, Walls AF, Kearley J, Humbles AA, Kolbeck R, Bjermer L, Newbold P, Erjefält JS.Eur Respir J. 2020 May 7;55(5):1900110. doi: 10.1183/13993003.00110-2019. Print 2020 May.PMID: 32060064 Free PMC article.
• IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation.Allinne J, Scott G, Lim WK, Birchard D, Erjefält JS, Sandén C, Ben LH, Agrawal A, Kaur N, Kim JH, Kamat V, Fury W, Huang T, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM.J Allergy Clin Immunol. 2019 Dec;144(6):1624-1637.e10. doi: 10.1016/j.jaci.2019.08.039. Epub 2019 Sep 25.PMID: 31562870 Free article.
• Bronchoscopic mucosal cryobiopsies as a method for studying airway disease. Hvidtfeldt M, Pulga A, Hostrup M, Sanden C, Mori M, Bornesund D, Larsen KR, Erjefält JS, Porsbjerg C.Clin Exp Allergy. 2019 Jan;49(1):27-34. doi: 10.1111/cea.13281. Epub 2018 Oct 12.PMID: 30244522 Clinical Trial.
• Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage. Scott IC, Majithiya JB, Sanden C, Thornton P, Sanders PN, Moore T, Guscott M, Corkill DJ, Erjefält JS, Cohen ES.Sci Rep. 2018 Feb 20;8(1):3363. doi: 10.1038/s41598-018-21589-2.PMID: 29463838 Free PMC article.
• Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis. Sanden C, Mori M, Jogdand P, Jönsson J, Krishnan R, Wang X, Erjefält JS.Immun Inflamm Dis. 2017 Sep;5(3):300-309. doi: 10.1002/iid3.164. Epub 2017 May 12.PMID: 28497614 Free PMC article.
• Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs. Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA.Nat Immunol. 2016 Jun;17(6):626-35. doi: 10.1038/ni.3443. Epub 2016 Apr 25.PMID: 27111143 Free PMC article.
• Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours. Braekeveldt N, Wigerup C, Tadeo I, Beckman S, Sandén C, Jönsson J, Erjefält JS, Berbegall AP, Börjesson A, Backman T, Øra I, Navarro S, Noguera R, Gisselsson D, Påhlman S, Bexell D.Cancer Lett. 2016 Jun 1;375(2):384-389. doi: 10.1016/j.canlet.2016.02.046. Epub 2016 Mar 18.PMID: 27000989 Free article.
• IL-17A and the Promotion of Neutrophilia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Roos AB, Sethi S, Nikota J, Wrona CT, Dorrington MG, Sandén C, Bauer CM, Shen P, Bowdish D, Stevenson CS, Erjefält JS, Stampfli MR.Am J Respir Crit Care Med. 2015 Aug 15;192(4):428-37. doi: 10.1164/rccm.201409-1689OC.PMID: 26039632
• IL-17A Is Elevated in End-Stage Chronic Obstructive Pulmonary Disease and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis. Roos AB, Sandén C, Mori M, Bjermer L, Stampfli MR, Erjefält JS.Am J Respir Crit Care Med. 2015 Jun 1;191(11):1232-41. doi: 10.1164/rccm.201410-1861OC.PMID: 25844618
• Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection. Kearley J, Silver JS, Sanden C, Liu Z, Berlin AA, White N, Mori M, Pham TH, Ward CK, Criner GJ, Marchetti N, Mustelin T, Erjefalt JS, Kolbeck R, Humbles AA.Immunity. 2015 Mar 17;42(3):566-79. doi: 10.1016/j.immuni.2015.02.011.PMID: 25786179 Free article.
• A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality. Holmkvist P, Roepstorff K, Uronen-Hansson H, Sandén C, Gudjonsson S, Patschan O, Grip O, Marsal J, Schmidtchen A, Hornum L, Erjefält JS, Håkansson K, Agace WW.Mucosal Immunol. 2015 May;8(3):545-58. doi: 10.1038/mi.2014.87. Epub 2014 Oct 1.PMID: 25269704 Free PMC article.